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Endometriosis

Ḍâri Wikipèḍia bhâsa Madhurâ, lombhung pangataowan mardhika
Endometriosis
Endometriosis as seen during laparoscopic surgery
Informasi umum
SpesialisasiLua error in Modul:WikidataIB at line 94: attempt to call field 'loadI18n' (a nil value).
PenyebabUnknown[1]
Faktor risikoFamily history[2]
Aspek klinis
Gejala dan tandaPelvic pain, infertility[1]
Awal munculUnknown. First symptoms appear at the age before 20–30 years old.[3][2][4]
DurasiLong term[1]
DiagnosisBased on symptoms, medical imaging, tissue biopsy[2]
Kondisi serupaPelvic inflammatory disease, irritable bowel syndrome, interstitial cystitis, fibromyalgia[1]
Tata laksana
PencegahanCombined birth control pills, exercise, avoiding alcohol and caffeine[2]
PerawatanNSAIDs, continuous birth control pills, intrauterine device with progestogen, surgery[2]
Distribusi dan frekuensi
Prevalensi10–15% of all women of reproductive age[7]
Kematian≈100 (0.0 to 0.1 per 100,000, 2015)[5][6]

Endometriosis iyâ arèya radang sè andi' hubungan sareng hormon estradiol/esterogen sè aropaaghi tombuna jaringan endometrium bân perambatan pembuluh ḍârâ, sampè' kalowar ḍâri rahim (pertumbuhan ectopik) bân asabâbaghi pelvic pain.[8] Endometriosis anḍi' hubungan bi' esterogen mènangka perkembangan bân simtoma sè ètimbulaghi bhâkal èlang pas ḍâtengnga menopause. Mangkana perawatan sè paling umum kaangghuy orèng sè sakè' radang jiya arèya kaguna'an terapi hormonal sè ginduksi kabâḍâ'ân hipoestrogenik. Esterogen arèya kalompo' hormon steroid sè èsekresi ovarium samarèna èstimulasi sareng FSH bân LH sè èsekresi sareng kelenjar hipofisis. Lebbi lanjut sekresi FSH bân LH èhambat sareng hormon GnRH sè sekresi sareng hipotalamus.

Endometriosis

Samarèna kista endometrium la abentu' sadâjânah, muncul simtoma hiperalgesia vaginal è bi' hiperalgesia otot tabu’. Jaringan è kista bhâkal asekresi sitokina antara laèn IL-1, IL-6, IL-8, bân IL-10, TNF-a, faktor tombu akadhi VERY bân NGF.

Biasana endometriosis abâtes bi' lapisan tabu’ otabâ permukaan organ tabu’. Endometrium sè sala kennengngan rèya biyasana nyeddhing ka ovarium (indung telur) bân ligamen penyokong rahim. Endometrium jughân bisa nyeddhing ka lapisan lowar usus alos bân usus rajâ, ureter (saluran sè ahubungaghi ginjal bân kandung kemmè), kandung kemmè, farji', jaringan parut è ḍâlem tabu’, otak lapisan rongga dada. Kadhâng jaringan endometrium tombu è ḍâlem paru-paru. Endometriosis bisa ètoronaghin bân lebbi sering ètemmoaghin è katoronan dâ'-adâ' (èbo', ana' binè', tarètan binè'). Faktor laen sè ningkat aghi resiko bâdanah endometriosis arèya andi' rahim sè abnormal, ngalahiraghi dâ'-adâ' è omor è attas 30 taon bân kolè' potè.

Endometriosis èkèraaghi kadhâddhiyan è 10-15% orèng binè’ sè omor 25-44 taon, 25-50% orèng binè’ mandul bân bisa jugân kadhâddiyan è omor ḍhât-ngoḍhâdhân. Endometriosis sè berrâ' bisa nyebabaghi mandul karana alanglang jhâlanna sel telor ḍâri ovarium ka rahim.

  1. 1,0 1,1 1,2 1,3 Kasala'an pameṭṭèkan: Tag <ref> tidak sah; tidak ditemukan teks untuk ref bernama Bulletti2010
  2. 2,0 2,1 2,2 2,3 2,4 Kasala'an pameṭṭèkan: Tag <ref> tidak sah; tidak ditemukan teks untuk ref bernama WH2014
  3. Horne AW, Missmer SA (November 2022). "Pathophysiology, diagnosis, and management of endometriosis". BMJ. 379: e070750. doi:10.1136/bmj-2022-070750. hdl:20.500.11820/a2c07717-cf08-4119-b0f4-b7f8aa50193ealt=Dapat diakses gratis. PMID 36375827 Periksa nilai |pmid= (bantuan). 
  4. McGrath PJ, Stevens BJ, Walker SM, Zempsky WT (2013). Oxford Textbook of Paediatric Pain. OUP Oxford. hlm. 300. ISBN 978-0-19-964265-6. Diarsipkan dari versi asli tanggal 10 September 2017. 
  5. Kasala'an pameṭṭèkan: Tag <ref> tidak sah; tidak ditemukan teks untuk ref bernama GBD2015Pre
  6. Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. (GBD 2015 Mortality and Causes of Death Collaborators) (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/S0140-6736(16)31012-1. PMC 5388903alt=Dapat diakses gratis. PMID 27733281. 
  7. Parasar P, Ozcan P, Terry KL (2017). "Endometriosis: Epidemiology, Diagnosis and Clinical Management". Curr Obstet Gynecol Rep. 6 (1): 34–41. doi:10.1007/s13669-017-0187-1. PMC 5737931alt=Dapat diakses gratis. PMID 29276652. 
  8. "Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat" (Inggris). Program in Neuroscience, Florida State University; Guohua Zhang, Natalia Dmitrieva, Yan Liu, Kristina A. McGinty, and Karen J. Berkley. Aksès tanggâl 2011-09-04.